Advanced receiver structures for mobile MIMO multicarrier communication systems

Beyond third generation (3G) and fourth generation (4G) wireless communication systems are targeting far higher data rates, spectral efficiency and mobility requirements than existing 3G networks. By using multiple antennas at the transmitter and the receiver, multiple-input multiple-output (MIMO) technology allows improving both the spectral efficiency (bits/s/Hz), the coverage, and link reliability of the system. Multicarrier modulation such as orthogonal frequency division multiplexing (OFDM) is a powerful technique to handle impairments specific to the wireless radio channel. The combination of multicarrier modulation together with MIMO signaling provides a feasible physical layer technology for future beyond 3G and fourth generation communication systems. The theoretical benefits of MIMO and multicarrier modulation may not be fully achieved because the wireless transmission channels are time and frequency selective. Also, high data rates call for a large bandwidth and high carrier frequencies. As a result, an important Doppler spread is likely to be experienced, leading to variations of the channel over very short period of time. At the same time, transceiver front-end imperfections, mobility and rich scattering environments cause frequency synchronization errors. Unlike their single-carrier counterparts, multi-carrier transmissions are extremely sensitive to carrier frequency offsets (CFO). Therefore, reliable channel estimation and frequency synchronization are necessary to obtain the benefits of MIMO OFDM in mobile systems. These two topics are the main research problems in this thesis. An algorithm for the joint estimation and tracking of channel and CFO parameters in MIMO OFDM is developed in this thesis. A specific state-space model is introduced for MIMO OFDM systems impaired by multiple carrier frequency offsets under time-frequency selective fading. In MIMO systems, multiple frequency offsets are justified by mobility, rich scattering environment and large angle spread, as well as potentially separate radio frequency - intermediate frequency chains. An extended Kalman filter stage tracks channel and CFO parameters. Tracking takes place in time domain, which ensures reduced computational complexity, robustness to estimation errors as well as low estimation variance in comparison to frequency domain processing. The thesis also addresses the problem of blind carrier frequency synchronization in OFDM. Blind techniques exploit statistical or structural properties of the OFDM modulation. Two novel approaches are proposed for blind fine CFO estimation. The first one aims at restoring the orthogonality of the OFDM transmission by exploiting the properties of the received signal covariance matrix. The second approach is a subspace algorithm exploiting the correlation of the channel frequency response among the subcarriers. Both methods achieve reliable estimation of the CFO regardless of multipath fading. The subspace algorithm needs extremely small sample support, which is a key feature in the face of time-selective channels. Finally, the Cramér-Rao (CRB) bound is established for the problem in order to assess the large sample performance of the proposed algorithms.reviewe

Agritechnica 2009 - Neuerungen begeistern trotz schwieriger Zeiten

Auf der Agritechnica 2009 präsentierten vom 8. bis zum 14. November trotz wirtschaftlicher Krise mehr Aussteller als jemals zuvor Neuigkeiten rund um die Landtechnik. Unter der Vielzahl an Neuentwicklungen haben sich deutlich die Trends verbesserter Bedienkomfort, Elektrifizierung von Anbaugeräten und Zugmaschinen, Verbrauchs- und Emissionsoptimierung sowie Effizienzsteigerung abgebildet. Der Fachbeitrag verschafft Interessenten einen Überblick über die Entwicklungstrends in der Landmaschinenbranche

Relating Profile Wall Root-Length Density Estimates to Monolith Root-Length Density Measurements of Cover Crops

Different methods have been proposed for in situ root-length density (RLD) measurement. One widely employed is the time-consuming sampling of soil cores or monoliths (MO). The profile wall (PW) method is a less precise, but faster and less laborious alternative. However, depth-differentiated functions to convert PW RLD estimates to MO RLD measurements have not yet been reported. In this study, we perform a regression analysis to relate PW results to MO results and determine whether calibration is possible for distinct crop groups (grasses, brassicas and legumes) consisting of pure and mixed stands, and whether soil depth affects this calibration. The methods were applied over two years to all crop groups and their absolute and cumulative RLD were compared using a linear (LR) and multiple linear (MLR) regression. PW RLD was found to highly underestimate MO RLD in absolute values and in highly rooted areas. However, a close agreement between both methods was found for cumulative root-length (RL) when applying MLR, highlighting the influence of soil depth. The level of agreement between methods varied strongly with depth. Therefore, the application of PW as the main RLD estimation method can provide reliable estimates of cumulative root distribution traits of cover crops.Peer Reviewe

The Vascular Impairment of Cognition Classification Consensus Study

H. Jokinen työryhmän jäsenenä.Introduction: Numerous diagnostic criteria have tried to tackle the variability in clinical manifestations and problematic diagnosis of vascular cognitive impairment (VCI) but none have been universally accepted. These criteria have not been readily comparable, impacting on clinical diagnosis rates and in turn prevalence estimates, research, and treatment. Methods: The Vascular Impairment of Cognition Classification Consensus Study (VICCCS) involved participants (81% academic researchers) from 27 countries in an online Delphi consensus study. Participants reviewed previously proposed concepts to develop new guidelines. Results: VICCCS had a mean of 122 (98-153) respondents across the study and a 67% threshold to represent consensus. VICCCS redefined VCI including classification of mild and major forms of VCI and subtypes. It proposes new standardized VCI-associated terminology and future research priorities to address gaps in current knowledge. Discussion: VICCCS proposes a consensus-based updated conceptualization of VCI intended to facilitate standardization in research. (C) 2016 the Alzheimer's Association. Published by Elsevier Inc. All rights reserved.Peer reviewe

Pre-hospital management protocols and perceived difficulty in diagnosing acute heart failure

Aim To illustrate the pre-hospital management arsenals and protocols in different EMS units, and to estimate the perceived difficulty of diagnosing suspected acute heart failure (AHF) compared with other common pre-hospital conditions. Methods and results A multinational survey included 104 emergency medical service (EMS) regions from 18 countries. Diagnostic and therapeutic arsenals related to AHF management were reported for each type of EMS unit. The prevalence and contents of management protocols for common medical conditions treated pre-hospitally was collected. The perceived difficulty of diagnosing AHF and other medical conditions by emergency medical dispatchers and EMS personnel was interrogated. Ultrasound devices and point-of-care testing were available in advanced life support and helicopter EMS units in fewer than 25% of EMS regions. AHF protocols were present in 80.8% of regions. Protocols for ST-elevation myocardial infarction, chest pain, and dyspnoea were present in 95.2, 80.8, and 76.0% of EMS regions, respectively. Protocolized diagnostic actions for AHF management included 12-lead electrocardiogram (92.1% of regions), ultrasound examination (16.0%), and point-of-care testings for troponin and BNP (6.0 and 3.5%). Therapeutic actions included supplementary oxygen (93.2%), non-invasive ventilation (80.7%), intravenous furosemide, opiates, nitroglycerine (69.0, 68.6, and 57.0%), and intubation 71.5%. Diagnosing suspected AHF was considered easy to moderate by EMS personnel and moderate to difficult by emergency medical dispatchers (without significant differences between de novo and decompensated heart failure). In both settings, diagnosis of suspected AHF was considered easier than pulmonary embolism and more difficult than ST-elevation myocardial infarction, asthma, and stroke. Conclusions The prevalence of AHF protocols is rather high but the contents seem to vary. Difficulty of diagnosing suspected AHF seems to be moderate compared with other pre-hospital conditions

TP53 mutations in functional corticotroph tumors are linked to invasion and worse clinical outcome

Corticotroph macroadenomas are rare but difficult to manage intracranial neoplasms. Mutations in the two Cushing’s disease mutational hotspots USP8 and USP48 are less frequent in corticotroph macroadenomas and invasive tumors. There is evidence that TP53 mutations are not as rare as previously thought in these tumors. The aim of this study was to determine the prevalence of TP53 mutations in corticotroph tumors, with emphasis on macroadenomas, and their possible association with clinical and tumor characteristics. To this end, the entire TP53 coding region was sequenced in 86 functional corticotroph tumors (61 USP8 wild type; 66 macroadenomas) and the clinical characteristics of patients with TP53 mutant tumors were compared with TP53/USP8 wild type and USP8 mutant tumors. We found pathogenic TP53 variants in 9 corticotroph tumors (all macroadenomas and USP8 wild type). TP53 mutant tumors represented 14% of all functional corticotroph macroadenomas and 24% of all invasive tumors, were significantly larger and invasive, and had higher Ki67 indices and Knosp grades compared to wild type tumors. Patients with TP53 mutant tumors had undergone more therapeutic interventions, including radiation and bilateral adrenalectomy. In conclusion, pathogenic TP53 variants are more frequent than expected, representing a relevant amount of functional corticotroph macroadenomas and invasive tumors. TP53 mutations associated with more aggressive tumor features and difficult to manage disease

Small Vessel Disease and Subcortical Vascular Dementia

Atherothromboembolism and intracranial small vessel disease are considered to be the main causes of cerebrovascular injury, which may lead to cognitive impairment and vascular dementia (VaD). VaD appears to be the second most common type of dementia with prevalence estimates of 10-15%. Cortical or multi-infarct dementia and subcortical vascular dementia (SVD) are suggested to be the two main forms of VaD. The main clinical features of SVD comprise decreased motor performance, early impairment of attention and executive function with slowing of information processing. SVD results from lacunar infarcts or multiple microinfarcts in the basal ganglia, thalamus, brainstem and white matter and are associated with more than 50% of the VaD cases. White matter changes including regions of incomplete infarction are usually widespread in VaD but their contribution to impairment of subcortical regions is unclear. While most of VaD occurs sporadically only a small proportion of cases bear clear familial traits. CADASIL is likely the most common form of hereditary VaD, which arises from subcortical arteriopathy. SVD needs unambiguous definition to impact on preventative and treatment strategies, and critical for selective recruitment to clinical trials